Effectiveness of Different Toothpastes in Treating White Spot Lesions
Launched by MANSOURA UNIVERSITY · Nov 10, 2023
Trial Information
Current as of November 05, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is looking at how effective different types of toothpastes are in treating white spot lesions, which are small, light-colored spots on teeth that can appear after orthodontic treatment (like braces). The three types of toothpaste being compared are zinc-carbonated nano-hydroxyapatite, arginine, and fluoride. Researchers will use special computer software and X-ray technology to analyze how well each toothpaste works in helping to improve these spots on the teeth.
To participate in this study, you need to have recently finished wearing braces (within the last week) and have at least one white spot lesion on the front teeth that meets specific criteria. Unfortunately, if you've had any previous treatment for these spots, have cavities, or certain other dental issues, you won't be eligible to join. If you do participate, you can expect to use one of the test toothpastes and be part of an important study that could help improve dental care for others in the future!
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Completion of fixed appliance therapy within the past 1 week.
- • Presence of at least one post-orthodontic white spot lesion on the labial surfaces of the six maxillary anterior teeth with a score of 1 or 2 on International Caries Detection and Assessment System (ICDAS II).
- Exclusion Criteria:
- • Previous or planned treatment of WSLs.
- • Cavitated enamel surface.
- • Teeth with any composite restorations, veneers, crowns.
- • Surface defects (developmental defects, fluorosis, intrinsic and extrinsic discolorations, etc.).
- • Smoking habits.
About Mansoura University
Mansoura University is a prestigious academic institution located in Egypt, renowned for its commitment to advancing medical research and education. As a clinical trial sponsor, it leverages its extensive resources and expertise in various fields of healthcare to facilitate innovative research initiatives aimed at improving patient outcomes. The university collaborates with a network of healthcare professionals and researchers to conduct high-quality clinical trials, focusing on addressing critical health challenges through rigorous scientific methodologies. Its dedication to ethical research practices and adherence to regulatory standards underscores its role as a leader in the medical research community.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Mansoura, Egypt
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported