High Frequency Imaging in Cerebral Amyloid Angiopathy

Launched by MARTIN DICHGANS · Nov 7, 2023

Keywords

ClinConnect Summary

The HIFI-CAA study is investigating a condition called cerebral amyloid angiopathy (CAA), which is common in older adults and can lead to serious problems like brain bleeding, disability, and memory issues. The researchers want to learn more about specific brain changes in CAA patients, particularly a type of brain bleeding known as cortical superficial siderosis (cSS) and other related lesions. By using advanced imaging techniques every month, they hope to understand how these changes happen and what they mean for patients' health.

To join this study, participants need to be diagnosed with probable CAA and show certain signs like cSS or previous brain bleeding in specific areas. They should not have bleeding in deeper parts of the brain or other conditions that could cause similar symptoms. Participants will attend regular MRI scans to monitor their brain health over time. This study is important because it aims to improve understanding of CAA, which could lead to better treatments for those affected.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Probable CAA according to the modified Boston criteria with evidence of
• • 1. cSS or fSAH
• • 2. lobar ICH survivors without cSS or fSAH
• • Absence of ICH or microbleed in deep locations (basal ganglia, thalamus, brain stem)
• • Absence of infratentorial siderosis or infratentorial SAH
• • MR-/CT-/DS-angiography without evidence of cerebral aneurysm, AVM, AV-fistula or other possible etiology for the observed haemorrhagic manifestations
• • No history of head trauma resulting in loss of consciousness or radiologically visible traumatic brain injury
• • Written informed consent by patient herself/himself prior to study enrolment
• Exclusion Criteria:
• • Unwillingness to participate in high-frequency (monthly) follow-up
• • Severe medical condition with expected life expectancy \<1 year
• • Contraindications for MRI (following local guidelines of the respective study center)