Technical Feasibility Study of Ultrasound Muscle Imaging in Antenatal Ultrasound

Launched by UNIVERSITY HOSPITAL, GRENOBLE · Nov 9, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at a new way to use ultrasound technology to check the muscles of unborn babies for a condition called Arthrogryposis Multiplex Congenita (AMC), which affects joint movement. The study will focus on pregnant women, both those considered low-risk and high-risk for developing this condition, during a specific point in their pregnancy—between 21 to 24 weeks. The goal is to see how well muscle ultrasound can identify signs of muscle weakness.

To participate, women need to be pregnant with a single baby and at the right stage of pregnancy. High-risk candidates might have already been identified as having joint or movement issues in previous ultrasounds. It's important to note that the trial has not started recruiting participants yet, and it will take place at certain hospitals in Lyon and Grenoble. Women who meet the criteria will be asked to sign a consent form and can expect to have additional ultrasounds to help doctors learn more about using this technique for better prenatal care.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Any pregnant woman consulting in one of the two obstetric gynecology departments in connection with the CPDPN (Multidisciplinary Prenatal Diagnostic Centers) of the University hospitals of Lyon or Grenoble.
• • Mono-embryonic pregnancy.
• • Gestational ages retained on the first dating ultrasound or the 1st trimester ultrasound between 21-24 amenorrhea weeks.
• • For women at "high risk": diagnosis during ultrasound of the 1st, 2nd, or 3rd trimesters, of an abnormality of position / deformation of one or more joints, and / or an abnormality of fetal movements on screening ultrasound or interrogation (population group at "high risk of AMC").
• • Regulatory criteria: adults, affiliated to a social security scheme, having signed a consent
• Exclusion Criteria:
• • Multiple pregnancies, and / or non-progressive .
• • Obese women (BMI \> 30 in early pregnancy)
• • Subject in a period of exclusion from another study
• • Subject under administrative or judicial supervision
• • Subject who cannot be contacted in case of emergency