The Effect of a 2-week Preoperative Vegan Diet Versus Omnivorous Diet on the Protein Turnover in the Osteoarthritic Knee

Launched by WAGENINGEN UNIVERSITY · Nov 8, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how a 2-week vegan diet compares to a regular omnivorous diet in older adults who have osteoarthritis of the knee and are preparing for knee surgery. The main goal is to see if these diets affect the way the body builds proteins in various parts of the knee, which could impact recovery after surgery. Additionally, the trial will look at whether the diets influence blood pressure and levels of certain amino acids in the blood.

To participate in this study, individuals must be between 60 and 80 years old, have a Body Mass Index (BMI) between 20-32, and be scheduled for knee replacement surgery. They should also be mentally competent and not have followed a vegetarian or vegan diet in the six months before the study. Participants will receive either the vegan or omnivorous diet for two weeks and will be monitored for their health and how well their bodies are responding to the diets. This trial is currently recruiting individuals who meet these criteria and are interested in learning more about how diet can impact knee health and recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Written informed consent;
• • Patients scheduled for total knee arthroplasty;
• • BMI between 20-32 kg/m2;
• • Aged 60 - 80 years;
• • Mentally competent, as judged by the treating physician;
• Exclusion Criteria:
• • Following a vegetarian or vegan diet or a diet that affects protein intake during the six months prior to the study;
• • Participating in a structured progressive exercise training program in the past three months;
• • Lost more than 4 kg body weight during three months prior to the study;
• • Chronic use of medications that affect protein metabolism (i.e. systemic corticosteroids, or prescription strength acne medications);
• • Being diagnosed with one of the following: diabetes mellitus, rheumatoid arthritis, peripheral artery disease Fontaine III or IV, COPD GOLD III or IV, neoadjuvant chemotherapy or radiotherapy, phenylketonuria, collagen disorders (e.g. Marfan and Ehler-Danlos);
• • Alcohol abuse;
• • Surgical intervention to the knee in the past four weeks;
• • Total parenteral nutrition at day of surgery;
• • Glomerular filtration rate (GFR) \<20 mL/min/1.73 m2;
• • Allergic or intolerant to any product included in the diets;
• • Osteoarthritis of the knee secondary to septic arthritis, osteonecrosis, fracture, osteochondritis dissecans, or malignant processes;
• • Any other medical condition that may interfere with the safety of the participants or the outcome parameters, in the investigators judgement;
• • Not willing to stop nutritional supplements, with the exception of vitamin D and supplements on medical advice.
• • Investigator's uncertainty about the willingness or ability of the participant to comply with the protocol instructions;
• • Participation in other studies that may have an impact on the outcomes during the three months before the start of the current study.