Diastology-Guided Management of Decompensated Heart Failure

Launched by MCMASTER UNIVERSITY · Nov 13, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring a new approach to manage patients with decompensated heart failure, a serious condition where the heart struggles to pump enough blood. The study aims to see if using a specific type of heart monitoring called hemodynamic monitoring, along with a targeted treatment plan, can help improve outcomes for patients. More than 30% of individuals with this condition end up back in the hospital within 90 days, so finding better management strategies is important.

To participate in this trial, candidates need to be at least 18 years old and have a specific type of heart failure with a reduced ability to pump blood. They should also be in a normal heart rhythm and agree to participate in the study. However, individuals with certain heart conditions, like severe valve disease or irregular heart rhythms, won't be eligible. If you or a loved one qualifies, participants can expect to undergo non-invasive heart monitoring and receive tailored treatment based on their individual needs. This study has not started recruiting participants yet, but it represents an exciting step towards improving heart failure management.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥18 years at the time of enrolment
• • 2. Decompensated heart failure with reduced ejection fraction (≤40%)
• • 3. Sinus rhythm without conduction abnormalities (second-degree Mobitz II, third-degree, permanent pacemaker)
• • 4. Written informed consent from either the patient or a substitute decision maker
• Exclusion Criteria:
• • 1. Mitral annular calcification (at least moderate or severe)
• • 2. Moderate or severe aortic or mitral valvular heart disease, or history of prosthetic mitral valve
• • 3. Atrial fibrillation or flutter
• • 4. History of non-diagnostic echocardiogram
• • 5. Hemodialysis