Dexmedetomidine, Ozone and Dexamethasone Local Injection in Carpal Tunnel Syndrome for Pain Relief

Launched by TANTA UNIVERSITY · Nov 13, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness of three different treatments—Dexmedetomidine, Ozone, and Dexamethasone—when injected into the area affected by carpal tunnel syndrome (CTS) to help relieve pain. Carpal tunnel syndrome occurs when the median nerve, which runs through the wrist, becomes compressed, causing symptoms like numbness and pain. The goal of this trial is to see which of these treatments works best for easing pain in patients who have mild to moderate symptoms that have lasted at least three months.

To participate in this study, individuals need to be between 20 and 60 years old and have certain signs of carpal tunnel syndrome, confirmed by an ultrasound and nerve tests. However, those with severe symptoms, previous treatments, or certain medical conditions, such as pregnancy or severe heart disease, will not be eligible. If you join the trial, you'll receive one of the treatments and will be asked to rate your pain before and after the injection. This research aims to find better ways to manage carpal tunnel syndrome and improve the quality of life for those affected.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age from 20 to 60 years.
• • Both sexes.
• • Patients with ultrasonographic evidence of mild-to-moderate carpal tunnel syndrome (CTS).
• • Inclusion criteria will include numbness and pain in the median nerve (MN) distribution persisting for minimum of 3 months , nerve conduction studies (NCS) consistent with carpal tunnel syndrome (CTS) as per the American Association of Neuromuscular and Electro diagnostic Medicine (AANEM) guidelines, and an median nerve (MN) cross-sectional area (CSA)at the wrist \>12 mm2 suggesting mild-to-moderate CTS forms.
• Exclusion Criteria:
• • Patient refusal.
• • Patients with severe symptoms and signs of CTS as identified per the American Association of Neuromuscular and Electro diagnostic Medicine (AANEM) guidelines,\[14\] as this is an indication for surgery,
• • Patients who show improvement on medical treatment,
• • Previous surgical or injectional CTS treatment,
• • Pregnancy ,co existence of brachial plexopathy, or thoracic outlet syndrome, polyneuropathy, radiculopathy and peripheral nerve lesion in upper limb.
• • Severe cardiovascular disease
• • Morbid obese patients (body mass index (BMI) of \>35 kg/m2)
• • Infection at site of injection.
• • Bleeding diathesis.
• • History of thyroid deficiency, uncontrolled diabetes mellitus , rheumatoid arthritis and history of glucose-6-phosphate dehydrogenase (G6PD) deficiency
• • History of Ozone or Dexmedetomidine allergy.
• • End stage renal and hepatic disease.
• • History of inflammatory joint , connective tissue disorders, , burns, any local tissue contractures and history of wrist trauma.
• • Patients who will not consent to completing The visual analogue scale (VAS) for pain or nerve conduction study before and after injection.