Mechanisms of Fasting Induced Reduction in Energy Expenditure

Launched by ETH ZURICH · Nov 10, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how fasting affects the body's energy use, specifically looking at why some people experience a bigger change in their metabolism than others when they fast. The researchers will first observe how a 24-hour fast influences the body's basic energy needs, known as the basal metabolic rate. Then, participants who show different reactions will take part in the main study, where they will compare the effects of fasting for 24 hours versus 8 hours. The study will also explore how the body responds to food after fasting and the role of thyroid hormones in these changes.

To join this study, participants need to be between 18 and 40 years old and have a body mass index (BMI) between 18.0 and 27.0. However, individuals with certain health conditions, such as diabetes or heart disease, or those who have used drugs recently, cannot participate. Those who join can expect to undergo some tests related to their metabolism and provide a small sample of fat tissue for further analysis. It's a great opportunity to contribute to important research on how our bodies adapt to fasting!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age: 18 to 40 years
• • Body mass index 18.0 to 27.0 kg/m²
• * Exclusion Criteria:
• • Chronic conditions necessitating medical treatment (e.g., renal failure, hepatic dysfunction, cardiovascular disease, diabetes mellitus),
• • Known or suspected non-compliance, drug or alcohol abuse,
• • Inability to follow the procedures of the study
• • Participation in another study with investigational drug within the 30 days preceding and during the present study,
• • Previous enrolment into the current study,
• • Enrolment of the investigator, his/her family members, employees and other dependent persons,
• • Hypothyroidism or hyperthyroidism
• • Pregnant, breastfeeding and menopausal women