The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma
Launched by BEIJING TIANTAN HOSPITAL · Nov 16, 2023
Trial Information
Current as of July 25, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is investigating how different anesthetics, specifically dexmedetomidine and propofol, affect brain connections in patients undergoing surgery for a type of brain tumor called supratentorial glioma. Researchers want to understand how these anesthetics may influence cognitive function after surgery, particularly looking at the risk of postoperative delirium, which is a type of confusion that can happen after surgery. By using advanced brain imaging techniques, the study aims to explore changes in brain networks during anesthesia and how these changes relate to thinking and memory.
To participate in this trial, individuals must be at least 18 years old, diagnosed with a unilateral supratentorial glioma confirmed by an MRI, and generally healthy (classified as ASA I-II, which means they have a low risk for surgery). However, those with certain medical histories, such as past brain surgeries, mental health issues, or severe heart problems, cannot take part. Participants can expect to undergo surgery with one of the anesthetics being studied and have their brain activity monitored through imaging to help researchers learn more about the impact of anesthesia on brain function. This research could lead to better ways to manage patient care during and after brain surgery.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Diagnosed as unilateral supratentorial glioma by MRI
- • Selective operation
- • Age over 18 years old
- • ASA I-II
- • Right handedness
- Exclusion Criteria:
- • History of cerebrovascular disease, brain trauma, chemotherapy and radiotherapy, or psychotropic drugs
- • History of intracranial surgery
- • Drug and/or alcohol abuse
- • History of dementia or mental illness
- • Pregnant or lactating women
- • Contraindications for MRI
- • Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block
- • Severe hepatic or renal dysfunction
About Beijing Tiantan Hospital
Beijing Tiantan Hospital, affiliated with Capital Medical University, is a leading medical institution in China renowned for its expertise in neurology, neurosurgery, and various other specialties. As a prominent clinical trial sponsor, the hospital is committed to advancing medical research and improving patient outcomes through innovative studies. With a focus on high-quality clinical trials, Beijing Tiantan Hospital adheres to rigorous ethical standards and regulatory requirements, fostering collaboration with academic institutions and industry partners to facilitate the development of cutting-edge therapies and interventions. Its state-of-the-art facilities and experienced research team enable the hospital to play a pivotal role in the global medical research landscape.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Beijing, Beijing, China
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported