Comparing the Effect of siSPARC Microneedle Patch Versus siSPARC+siLR4A Microneedle Patch on Post-surgical Scars
Launched by NATIONAL SKIN CENTRE · Nov 17, 2023
Trial Information
Current as of July 22, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying two different types of patches that are applied to post-surgical scars to see which one helps improve their appearance better. One patch, called siSPARC, contains tiny needles that deliver a special treatment designed to help heal the skin. The other patch combines siSPARC with an additional treatment called siLR4A. Researchers want to find out if using the combined patch gives better results than using siSPARC alone.
To participate in this trial, you need to be an adult between the ages of 21 and 75 who has had surgery with stitches removed within the last two weeks. Your wound should be healed properly, and you should not be pregnant, have an infection, or have any allergies to the patch's ingredients. If you choose to join, you will apply one of the patches daily for a set period. This study is currently recruiting participants, and it aims to improve treatments for scars, which can be important for both appearance and confidence after surgery.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Adult
- • Age 21-75
- • 2 weeks (+/- 7 days) after surgical operation with incision into the dermis
- • Post-stitch removal when stitches were applied
- • Wound closure/union achieved
- Exclusion Criteria:
- • Pregnant or lactating participant
- • Participants with wound infection
- • Participants assessed to be uncooperative or unable to self-administer the interventions
- • Participants with known contact allergy to ingredients in the patch formulation (comprising hyaluronic acid, siRNA and glue) and/or isopropyl alcohol
- • Participants who are unable to personally consent (for e.g., cognitively impaired)
About National Skin Centre
The National Skin Centre (NSC) is a premier clinical research institution dedicated to advancing dermatological care through innovative research and clinical trials. As a leading sponsor of cutting-edge studies, NSC focuses on the evaluation of new treatments and therapies for a wide range of skin conditions, with a commitment to improving patient outcomes and enhancing the understanding of dermatological health. Leveraging a multidisciplinary team of experts and state-of-the-art facilities, the National Skin Centre strives to contribute to the global body of dermatological knowledge, ensuring that patients benefit from the latest advancements in skin health.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Singapore, , Singapore
Patients applied
Trial Officials
Hong Liang Tey
Principal Investigator
National Skin Centre
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported