Development of a High-speed Multimodal Photoacoustic/Ultrasound System for Functional Imaging of the Neonatal Brain

Launched by SECOND AFFILIATED HOSPITAL, SCHOOL OF MEDICINE, ZHEJIANG UNIVERSITY · Nov 14, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new imaging technology that aims to improve how doctors see and understand the brains of newborns who may have experienced a lack of oxygen or blood flow at birth, known as hypoxia-ischemia. The researchers are developing a special system that combines two imaging methods—photoacoustic and ultrasound—to give detailed pictures of the brain without using any harmful radiation or contrast dyes. This non-invasive approach will help doctors diagnose brain issues in newborns more accurately and earlier than traditional imaging methods.

To participate in this trial, infants must be between 1 to 7 days old, weigh between 2.5 kg and 4 kg, and have been diagnosed with hypoxic-ischemic encephalopathy. The trial is open to all genders. Participants will undergo imaging tests that are safe and do not require any painful procedures. This study is important because it could lead to better identification and treatment of brain injuries in newborns, helping to improve their long-term health outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ① All patients were clinically diagnosed as hypoxic-ischemic encephalopathy. ② infants born within 1-7 days (including 7 days); ③ The gestational age was 37-42 weeks; ④ body weight between 2.5kg and 4kg; ⑤ Color Doppler ultrasound and magnetic resonance imaging were performed in all patients. ⑥ Complete clinical records
• Exclusion Criteria:
• • ① Children with contraindications to MRI examination; ② Brain tumor, congenital heart disease; ③ unclear clinical diagnosis; ④ a definite history of intrauterine infection; ⑤ image quality affects the diagnosis of newborns; ⑥ Lack of complete clinical medical records.