Bronchial Epithelium of Children With Post-infectious Bronchiolitis Obliterans

Launched by INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, FRANCE · Nov 14, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a condition called bronchiolitis obliterans (BO), which can happen in children after a serious lung infection, often caused by viruses like adenovirus or rhinovirus. The goal of the study is to look at the nasal lining of young children to understand how it might change in those who go on to develop BO. Researchers want to find out if there are differences in the nasal cells of children who have viral infections and later develop BO compared to those who do not.

Eligible participants are children aged 1 month to 6 years who have been hospitalized with a confirmed adenovirus or rhinovirus infection. Parents will need to read, understand, and sign a consent form for their child to participate. During the study, children will have nasal samples taken, and if they develop BO, additional tests will be done to gather more information about their condition. This research aims to help improve our understanding of bronchiolitis obliterans and eventually lead to better treatments for affected children.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Children from 1 month to 6 years hospitalized at the Timone Enfant University Hospital
• • 2. Diagnosis of an adenovirus or rhinovirus respiratory infection confirmed on a nasal swab, made upon arrival as part of the child's initial care
• • 3. Consent form read, understood, approved and signed by parents before any study procedure
• • 4. Affiliation to a social security scheme or beneficiary of such a scheme
• The inclusion criteria for children who were not hospitalized when diagnosed with an adenovirus and rhinovirus respiratory infection at the Timone Enfant University Hospital are:
• • 1. Children from 1 month to 6 years old transferred to the Timone Enfant University Hospital
• 2. Show the following signs:
• • has. Clinical: clinical signs persist 6 weeks after a viral infection: tachypnea, wheezing and/or persistent hypoxemia b. Scan: mosaic appearance +/- bronchiectasis, atelectasis vs. +/- EFR if performed: obstructive ventilatory disorder not or only slightly reversible after bronchodilators
• • 3. Consent form read, understood, approved and signed by parents before any study procedure
• • 4. Affiliation to a social security scheme or beneficiary of such a scheme
• Exclusion Criteria:
• • 1. Refusal of participation in the study by the family will be a reason for non-inclusion, as well as in the absence of parental authority.
• • 2. The existence of an underlying chronic pulmonary pathology (e.g. cystic fibrosis, ciliary dyskinesia).
• • 3. A coagulation pathology.