Effect of Ketamine on Intraoperative Motor Evoked Potentials

Launched by UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · Nov 14, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of ketamine, a medication commonly used for anesthesia, on motor function during surgery for patients having spinal procedures. Specifically, researchers want to see how different doses of ketamine impact the signals that show how well the nerves and muscles are working while patients undergo thoracolumbar spinal fusions. This trial is open to adults aged 18 and older who are scheduled for these types of surgeries, but those with certain health conditions, like severe high blood pressure or a history of heart problems, cannot participate.

If you decide to join the trial, you will receive a standard anesthetic for your surgery, and along with that, you’ll get increasing doses of ketamine. The medical team will measure your motor responses at each dose to see how ketamine affects your nerve and muscle function. It's important to know that this trial is currently recruiting participants, and your involvement could help improve our understanding of how to enhance surgical outcomes for spinal surgeries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients (\>18 years of age) undergoing posterior spinal fusions.
• Exclusion Criteria:
• • Sensitivity or allergy to ketamine.
• • Schizophrenia or other psychotic conditions
• • Uncontrolled hypertension with systolic blood pressure greater than 180 mmHg
• • Myocardial Infarction
• • Large vascular aneurysms
• • Patients on ketamine as outpatient therapy.