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Search / Trial NCT06141668

Optimal Stimulation Parameters to Disrupt Epileptiform Activity

Launched by MASSACHUSETTS GENERAL HOSPITAL · Nov 15, 2023

Trial Information

Current as of July 25, 2025

Recruiting

Keywords

ClinConnect Summary

This clinical trial is studying how to improve electrical stimulation treatments for people with refractory epilepsy, which means their seizures do not respond well to traditional medications. Researchers are looking to find the best settings for this stimulation so that it can effectively reduce seizure activity in the brain. They will compare what they’ve learned from animal studies to what doctors currently use in practice, hoping to find a more effective approach.

To participate in this trial, individuals must be undergoing a specific brain test called intracranial EEG at Massachusetts General Hospital as part of their evaluation for epilepsy surgery. This study is open to all genders and is currently recruiting participants. It's important to note that those who have very low spike activity in their brain waves (less than 0.5 spikes per minute) will not be eligible. Participants can expect to contribute to important research that could improve treatment options for epilepsy, while also receiving close monitoring and support throughout the trial.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • - Undergoing intracranial EEG investigation at Massachusetts General Hospital during presurgical epilepsy evaluation
  • Exclusion Criteria:
  • - Baseline spike ripple rate \< 0.5/min.

About Massachusetts General Hospital

Massachusetts General Hospital (MGH) is a leading academic medical center located in Boston, Massachusetts, renowned for its commitment to advancing medical research and patient care. As a prominent teaching hospital affiliated with Harvard Medical School, MGH plays a pivotal role in clinical trials across a wide range of disciplines, including cardiology, oncology, neurology, and more. The institution is dedicated to fostering innovative research that translates into effective therapies and improved health outcomes. MGH's Clinical Trials Office provides comprehensive support to facilitate the design, implementation, and management of clinical studies, ensuring adherence to the highest ethical standards and regulatory compliance. With a focus on collaboration and patient-centered care, MGH strives to enhance medical knowledge and contribute to the future of healthcare.

Locations

Boston, Massachusetts, United States

Patients applied

0 patients applied

Trial Officials

Catherine Chu, MD

Principal Investigator

Massachusetts General Hospital

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported