Optimal Stimulation Parameters to Disrupt Epileptiform Activity
Launched by MASSACHUSETTS GENERAL HOSPITAL · Nov 15, 2023
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying how to improve electrical stimulation treatments for people with refractory epilepsy, which means their seizures do not respond well to traditional medications. Researchers are looking to find the best settings for this stimulation so that it can effectively reduce seizure activity in the brain. They will compare what they’ve learned from animal studies to what doctors currently use in practice, hoping to find a more effective approach.
To participate in this trial, individuals must be undergoing a specific brain test called intracranial EEG at Massachusetts General Hospital as part of their evaluation for epilepsy surgery. This study is open to all genders and is currently recruiting participants. It's important to note that those who have very low spike activity in their brain waves (less than 0.5 spikes per minute) will not be eligible. Participants can expect to contribute to important research that could improve treatment options for epilepsy, while also receiving close monitoring and support throughout the trial.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • - Undergoing intracranial EEG investigation at Massachusetts General Hospital during presurgical epilepsy evaluation
- Exclusion Criteria:
- • - Baseline spike ripple rate \< 0.5/min.
About Massachusetts General Hospital
Massachusetts General Hospital (MGH) is a leading academic medical center located in Boston, Massachusetts, renowned for its commitment to advancing medical research and patient care. As a prominent teaching hospital affiliated with Harvard Medical School, MGH plays a pivotal role in clinical trials across a wide range of disciplines, including cardiology, oncology, neurology, and more. The institution is dedicated to fostering innovative research that translates into effective therapies and improved health outcomes. MGH's Clinical Trials Office provides comprehensive support to facilitate the design, implementation, and management of clinical studies, ensuring adherence to the highest ethical standards and regulatory compliance. With a focus on collaboration and patient-centered care, MGH strives to enhance medical knowledge and contribute to the future of healthcare.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Boston, Massachusetts, United States
Patients applied
Trial Officials
Catherine Chu, MD
Principal Investigator
Massachusetts General Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported