A Proof of Concept and Dose-finding Study of XXB750 in Patients With Heart Failure
Launched by NOVARTIS PHARMACEUTICALS · Nov 16, 2023
Trial Information
Current as of June 30, 2025
Terminated
Keywords
ClinConnect Summary
Eligible participants will be randomized to receive either subcutaneous (s.c.) XXB750 or placebo; or sacubitril/valsartan for 16 weeks, and then followed-up for 8 weeks
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Current symptom(s) of HF NYHA class II-III and LVEF \< 50%
- • Elevated NT-proBNP levels at screening.
- • Receiving standard of care background HF therapy.
- Exclusion Criteria:
- • Current acute decompensated HF or hospitalization for HF within 3 months prior to screening.
- • Current symptomatic hypotension (for example dizziness/presyncope).
- • K+ \> 5.4 mmol/L at screening
- • eGFR \< 30 mL/min/1.73m2 at screening
- • Other protocol-specific criteria may apply.
About Novartis Pharmaceuticals
Novartis Pharmaceuticals is a global healthcare company dedicated to reimagining medicine to improve and extend people's lives. With a strong focus on innovation, Novartis engages in the research, development, and commercialization of a broad range of therapies across various therapeutic areas, including oncology, cardiology, dermatology, and neuroscience. The company is committed to advancing scientific knowledge and patient care through clinical trials that prioritize safety and efficacy. Novartis leverages cutting-edge technology and collaborative partnerships to address unmet medical needs and deliver transformative treatments that enhance patient outcomes worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Roskilde, , Denmark
Heerlen, , Netherlands
Madrid, , Spain
Bergamo, Bg, Italy
Roma, Rm, Italy
Napoli, , Italy
Kiel, , Germany
Padova, Pd, Italy
Canton, Ohio, United States
Creteil, , France
Kawasaki City, Kanagawa, Japan
Malaga, Andalucia, Spain
Frankfurt, , Germany
Stuttgart, , Germany
Guangzhou, Guangdong, China
Groningen, , Netherlands
Leeuwarden, , Netherlands
Presov, , Slovakia
Jacksonville, Florida, United States
Pisa, Pi, Italy
Cona, Fe, Italy
Bergamo, Bg, Italy
Roma, Rm, Italy
Maebashi City, Gunma, Japan
Valencia, Comunidad Valenciana, Spain
Santiago De Compostela, Galicia, Spain
Varna, , Bulgaria
Shenyang, Liaoning, China
Chengdu, Sichuan, China
Beijing, , China
Hvidovre, , Denmark
Neuwied, , Germany
Balatonfured, , Hungary
Pordenone, Pn, Italy
Kosice, , Slovakia
Nitra, , Slovakia
Presov, Slovak Republic, Slovakia
Montpellier, , France
Brescia, Bs, Italy
Trieste, Ts, Italy
Taipei, , Taiwan
Reggio Emilia, Re, Italy
Pleven, , Bulgaria
Sofia, , Bulgaria
Beijing, , China
Wellington, Florida, United States
Nove Zamky, , Slovakia
Taichung, , Taiwan
Miami Lakes, Florida, United States
Guangzhou, Guangdong, China
Tianjin, Tianjin, China
Jinan, , China
Coburg, , Germany
Frankfurt, , Germany
Milano, Mi, Italy
Bardejov, , Slovakia
Utrera, Andalucia, Spain
East Yorkshire, , United Kingdom
Leipzig, , Germany
Ludwigshafen, , Germany
Shanghai, Shanghai, China
Kaohsiung, , Taiwan
Richmond, Virginia, United States
Plovdiv, , Bulgaria
Herlev, , Denmark
Messina, Me, Italy
Itabashi Ku, Tokyo, Japan
Sevilla, Andalucia, Spain
Groningen, , Netherlands
Richmond, Virginia, United States
Stara Zagora, , Bulgaria
Beziers Cedex, , France
Paris Cedex 10, , France
Rouen, , France
Berlin, , Germany
Ludwigshafen, , Germany
Papenburg, , Germany
Bikaner, Rajasthan, India
Martin, , Slovakia
El Palmar, Murcia, Spain
Saint Herblain Nantes, , France
Changchun, Jilin, China
Shreveport, Louisiana, United States
Matsumoto, Nagano, Japan
Marshall, Texas, United States
Xian, Shanxi, China
Koeln, , Germany
Ancona, An, Italy
Tainan, , Taiwan
Svidnik, , Slovakia
Gabrovo, , Bulgaria
Hachioji City, Tokyo, Japan
Rock Hill, South Carolina, United States
Fort Worth, Texas, United States
Brno, Czech Republic, Czechia
Dresden, Sachsen, Germany
Vila Nova De Gaia, , Portugal
Kawaguchi City, Saitama, Japan
Las Palmas De Gran Canaria, , Spain
Saint Louis, Missouri, United States
Inverness, Florida, United States
Lisboa, , Portugal
Chambray Les Tours, , France
Ormond Beach, Florida, United States
Inverness, Florida, United States
Schwaebisch Hall, , Germany
Huelva, Andalucia, Spain
Mosanmagyarovar, , Hungary
Alicante, , Spain
Rotterdam, Zuid Holland, Netherlands
Fort Washington, Maryland, United States
Dothan, Alabama, United States
Fort Washington, Maryland, United States
Tacoma, Washington, United States
Acworth, Georgia, United States
Blagoevgrad, , Bulgaria
Kyustendil, , Bulgaria
Budapest, Pest Megye, Hungary
Changzhou, Jiangsu, China
Gladbeck, , Germany
Toulouse 4, , France
Luoyang, Henan, China
Ponte Vedra, Florida, United States
Sagamihara, Kanagawa, Japan
Tullahoma, Tennessee, United States
Praha, , Czechia
Acworth, Georgia, United States
Lima, Ohio, United States
Miami Lakes, Florida, United States
Shreveport, Louisiana, United States
Tucson, Arizona, United States
Saint Louis, Missouri, United States
Ponte Vedra, Florida, United States
Saint Augustine, Florida, United States
Alexandria, Louisiana, United States
Troy, Michigan, United States
Saint Paul, Minnesota, United States
Huntsville, Alabama, United States
Dothan, Alabama, United States
Jacksonville, Florida, United States
Lexington, Kentucky, United States
Hammond, Louisiana, United States
Troy, Michigan, United States
Tullahoma, Tennessee, United States
Marshall, Texas, United States
Koriyama, Fukushima, Japan
Liberec, , Czechia
Jacksonville, Florida, United States
Miami, Florida, United States
Essen, Nordrhein Westfalen, Germany
Cypress, Texas, United States
Belgavi, , India
Tucson, Arizona, United States
Long Beach, California, United States
Rosedale, New York, United States
Columbia, South Carolina, United States
Dallas, Texas, United States
Houston, Texas, United States
Rennes, , France
Richmond, Indiana, United States
Nijmegen, , Netherlands
Kawasaki, Kanagawa, Japan
West Hartford, Connecticut, United States
Baltimore, Maryland, United States
Baltimore, Maryland, United States
New York, New York, United States
Cincinnati, Ohio, United States
Hachioji, Tokyo, Japan
Patients applied
Trial Officials
Novartis Pharmaceuticals
Study Director
Novartis Pharmaceuticals
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported