Alterations in Intestinal Microbiota, Metabolites, and Immune Cells in Allo-HSCT

Launched by THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY · Nov 16, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how changes in the gut, including bacteria and immune cells, can affect patients after they receive a stem cell transplant for blood-related disorders. Specifically, it looks at a condition called acute graft-versus-host disease (aGVHD), which can happen when the transplanted cells attack the recipient's body. The research involves 200 patients who have undergone this type of transplant and 50 healthy volunteers. By examining differences in gut health and immune responses, the study aims to understand how these factors relate to complications after the transplant, which could help improve patient care.

To be eligible for this trial, participants need to be patients receiving stem cell transplants for blood disorders. However, those with serious infections, autoimmune diseases, or certain other health issues won't be able to participate. If you join the study, you can expect to undergo tests that analyze your gut health and immune system. The insights gained from this research may lead to better methods for diagnosing and predicting complications in patients after their transplants.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with hematologic disorders undergoing allo-HSCT.
• Exclusion Criteria:
• • Patients with confirmed pathogenic intestinal infections and severe systemic infections at the time of sampling.
• • Diagnosis of autoimmune diseases, metabolic disorders, and chronic gastrointestinal diseases.
• • Pre-transplant diseases not in complete remission.
• • Post-transplant hematopoietic engraftment failure or pre-engraftment mortality.