The Effect of Continuous Positive Pressure Ventilation on Symptoms of Acute Mountain Sickness

Launched by UNIVERSITY OF COLORADO, DENVER · Nov 21, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a treatment called Continuous Positive Airway Pressure (CPAP) on people who experience Acute Mountain Sickness (AMS). AMS can happen when individuals travel to high altitudes, typically above 8,200 feet, and can cause symptoms like headaches, nausea, and dizziness. While there are some medications to help, they don’t work for everyone. This trial will look at whether using CPAP can reduce these symptoms and improve oxygen levels in the blood for those at high altitudes.

To participate in this study, you must be in Pheriche, Nepal, and have a score indicating AMS symptoms. However, certain health conditions, like uncontrolled asthma, heart problems, or pregnancy, may exclude you from participating. If eligible, you can expect to use the CPAP device during your stay in a high-altitude location, and your symptoms and oxygen levels will be monitored. This research aims to provide more information on how effective CPAP can be for treating AMS, potentially helping many travelers in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • present in Pheriche, Nepal;
• • Lake Louise score \> 1 (with or without formal AMS diagnosis)
• Exclusion Criteria:
• • History of chronic respiratory conditions (uncontrolled asthma, COPD, ILD)
• • obstructive sleep apnea (if currently using nighttime CPAP)
• • congestive heart failure
• • coronary artery disease
• • history of myocardial infarction
• • neurologic disorder
• • cognitive disorder
• • altered mental status
• • pregnancy
• • current use of supplemental oxygen
• • excessive facial hair,
• • claustrophobia