Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement

Launched by CASE WESTERN RESERVE UNIVERSITY · Nov 20, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how the bacteria in the mouth change when patients transition from having some teeth to having no teeth at all, and how this is affected by getting dental implants. The researchers want to understand how different types of implant materials might influence these changes, especially in patients with severe gum disease, known as periodontitis. By observing these changes, the study aims to gather important information that can help plan future research on dental health.

To be eligible for this trial, participants need to be at least 21 years old and diagnosed with advanced periodontitis, meaning they have significant gum disease. They should be planning to have all their teeth removed and replaced with dental implants. Participants should also have at least two implants that can be studied. However, there are certain health conditions, like needing long-term antibiotics or having specific infections, that would exclude someone from joining. If eligible, participants can expect to have their oral health monitored closely during the study, helping to improve understanding of dental health and implant success in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. At least 21 years of age
• • 2. Diagnosis of Stage III or IV periodontitis based on full mouth probing and full mouth x-rays
• • 3. Planned for full mouth extraction and replacement by dental implants.
• • 4. Rehabilitation with Implant supported restorations either maxilla and/ or mandible.
• • 5. At least 2 implants available for examination.
• • 6. No bone augmentation required.
• Exclusion Criteria:
• • 1. Conditions requiring chronic routine prophylactic use of antibiotics.
• • 2. Conditions requiring prolonged use of steroids.
• • 3. History of leukocyte dysfunction and deficiencies
• • 4. Bleeding disorders
• • 5. History of neoplastic disease requiring use of radiation or chemotherapy
• • 6. Metabolic bone disorders
• • 7. Uncontrolled endocrine disorder
• • 8. Use of any investigational drug or device within the 30 day period prior to implant surgery.
• • 10. Alcoholism or drug abuse 11. Patient infected with HIV 12. Condition or circumstances, in the opinion of the investigator, which would prevent completion of study participation or interfere with analysis of study results, such as history of non-compliance, unreliability.
• • Local Exclusion Criteria
• • 1. Local inflammation
• • 2. Mucosal disease such as erosive lichen planus
• • 3. History of local irradiation therapy
• • 4. Osseous lesion.
• • 5. Active infection with suppuration or fistula track.
• • 6. Persistent intraoral infection different than periodontitis