90% Effective Dose of Norepinephrine Infusions Under Intensive and Standard Treatment in Preeclamptic Patients

Launched by GENERAL HOSPITAL OF NINGXIA MEDICAL UNIVERSITY · Nov 28, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how effective a certain dose of norepinephrine infusions is in preventing low blood pressure after spinal anesthesia during a cesarean section for women with preeclampsia. Preeclampsia is a condition that can occur during pregnancy, leading to high blood pressure and potential complications. The researchers want to find out the right amount of norepinephrine that is helpful for these patients, comparing its use under two different treatment approaches: intensive and standard care.

To be eligible for this study, participants need to be women aged 18 to 45 who are either having their first baby or have had children before, and who are at least 32 weeks pregnant with only one baby. They also need to be scheduled for a cesarean section using spinal anesthesia. However, women with certain conditions, such as very high blood pressure, severe obesity, or other serious health issues, would not be included in the trial. If eligible, participants can expect to receive norepinephrine infusions during their surgery and will be monitored closely for their blood pressure and overall health. This study aims to ensure safer outcomes for mothers and their babies during cesarean deliveries in the context of preeclampsia.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 18-45 years
• • Primipara or multipara
• • Singleton pregnancy ≥32 weeks
• • American Society of Anesthesiologists physical status classification I to III
• • Scheduled for cesarean section under spinal anesthesia
• Exclusion Criteria:
• • Baseline blood pressure ≥160 mmHg
• • Body height \< 150 cm
• • Body weight \> 100 kg or body mass index (BMI) ≥ 40 kg/m2
• • Eclampsia or chronic hypertension
• • Hemoglobin \< 7g/dl
• • Fetal distress, or known fetal developmental anomaly