INtensity of OVarian Stimualtion and Euploid Embryos

Launched by FUNDACIÓN SANTIAGO DEXEUS FONT · Nov 30, 2023

Keywords

ClinConnect Summary

This clinical trial, called "INtensity of OVarian Stimulation and Euploid Embryos," is looking at how different levels of ovarian stimulation might affect fertility in women of advanced age. Specifically, it compares a milder approach to a more intense one to see if either affects the number of healthy embryos produced during a process called preimplantation genetic testing for aneuploidy (PGT-A). This study is currently recruiting women between the ages of 38 and 43 who are struggling with infertility and are considering in vitro fertilization (IVF).

To participate, women should have certain hormone levels (AMH) that fall within a specific range, be within a healthy weight range, and not have certain medical conditions that could interfere with the trial. Participants can expect to undergo IVF while following the study's protocols, and they will be closely monitored throughout the process. This research aims to provide valuable insights into the best practices for fertility treatments in older women, ultimately helping to improve their chances of having healthy embryos.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Infertile patients with indication for IVF
• • Undergoing preimplantation genetic screening cycles
• • AMH \>= 1.5 ng/ml and \< 3.5 ng/ml (AMH result of up to one year will be valid)
• • BMI 18.5 - 30 Kg/m2
• Exclusion Criteria:
• • Severe male factor requiring TESE (testicular sperm extraction)
• • AMH \< 1.5 ng/ml or \>= 3.5 ng/ml
• • Administration of any other drug potentially interfering with the treatment
• • Contraindication for hormonal treatment
• • Recent history of severe disease requiring regular treatment (clinically significant concurrent medical condition that could compromise subject safety or interfered with the trial assessment).
• • Monogenic disease to be detected with PGT-M