Sleep and Neuropathic Pain - Intervention Study on Pregabalin

Launched by HELSINKI UNIVERSITY CENTRAL HOSPITAL · Nov 24, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a medication called pregabalin on patients who experience neuropathic pain, which is a type of pain caused by nerve damage. The researchers want to find out if pregabalin not only helps reduce pain but also improves sleep quality, especially for those who have trouble sleeping. They will look at brain activity and sleep patterns before and after one month of taking pregabalin. Participants will fill out questionnaires and keep a sleep diary, as well as undergo some monitoring that includes wearing devices to track their sleep and having brain scans.

To join the study, participants should be between 18 and 75 years old and have chronic neuropathic pain that has lasted for more than three months. They should be experiencing moderate to severe pain. However, people with certain mental health conditions or those who cannot undergo brain scans due to medical reasons will not be eligible. Overall, this trial aims to understand how effectively pregabalin can help with both pain and sleep issues in patients suffering from neuropathic pain.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Chronic (duration \> 3 months) painful peripheral neuropathy
• • Pain moderate to severe (NRS ≥ 4/10) during the past week
• Exclusion Criteria:
• • psychotic depression, clinically significant bipolar disorder
• • contraindication for performing brain fMRI (metal in the body etc)