Effect of SNB on the QoR in Patients Undergoing Supratentorial Tumor Resection

Launched by SECOND AFFILIATED HOSPITAL, SCHOOL OF MEDICINE, ZHEJIANG UNIVERSITY · Nov 27, 2023

Keywords

ClinConnect Summary

This clinical trial is investigating how a scalp nerve block (SNB) can improve recovery for patients undergoing surgery to remove a tumor from the brain (specifically supratentorial tumors). After such surgeries, many patients experience significant pain, which can make their recovery more difficult. The study will involve 84 patients who will be randomly assigned to receive either the scalp nerve block or standard care. Researchers will look at how this treatment affects the patients' quality of recovery within the first 24 hours after surgery, as well as other factors like pain levels, nausea, and overall medical costs.

To participate in this trial, individuals must be between 18 and 65 years old, diagnosed with a supratentorial tumor, and scheduled for elective surgery with general anesthesia. However, there are some criteria that may exclude potential participants, such as certain health conditions or previous surgeries. If eligible, patients can expect close monitoring and support during their recovery process, and their experiences will contribute valuable information to help improve pain management in future surgeries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age between 18 and 65;
• • the diagnosis was supratentorial tumor;
• • scheduled for elective supratentorial craniotomy with general anesthesia ;
• • the American Society of Anesthesiologists physical status I-III;
• Exclusion Criteria:
• • the BMI≦18kg/m2 or BMI≧30kg/m2;
• • refusing to sign written informed consent;
• • anticipated surgery duration is too short (\<2 h) or too long (\>6 h);
• • liver or kidney dysfunction, severe cardiopulmonary failure or nervous system disease ;
• • with other malignancies ;
• • severe hematological disease and / or abnormal coagulation function;
• • fever, systemic and / or scalp infection;
• • tumors are metastases, aneurysms, hemangioma, or located in the skull base, or located in functional brain areas such as language and movement;
• • allergy to any drug used in this study;
• • a history of craniotomy tumor resection;
• • preoperative usage of antiinflammatory agents or analgesics;
• • pregnant women, lactating women, illiterate people, people with cognitive impairment, a history of mental illness, unable to communicate and complete the scale assessment;
• • patients with severe hemodynamic disturbances or other life-threatening complications during the operation, or those transferred to the intensive care unit (ICU) after surgery.