Vitrification of Oocytes Matured by CAPA-IVM

Launched by CENTRO DE FERTILIDAD Y REPRODUCCIÓN ASISTIDA, PERU · Dec 4, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the best way to freeze (or vitrify) eggs that have been matured in the lab. Some earlier research suggests that the freezing process might not work as well for eggs from certain types of follicles, which are small sacs in the ovaries. The goal of this study is to compare two different methods of freezing these matured eggs to see which one is more effective.

To participate in this trial, women aged 18 to 35 who have certain fertility conditions may be eligible. Specifically, candidates should either have a high number of small follicles or a good overall ovarian reserve, which means they have a healthy number of eggs available. Participants will need to be in good health, without significant issues in their uterus or ovaries, and not have any serious conditions that would prevent pregnancy. If you choose to take part, you will be helping researchers understand how to improve egg freezing techniques, which could benefit future fertility treatments.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Either
• • Patients with Polycystic ovary morphology: At least 25 follicles (2-9 mm) throughout the ovary and/or increased ovarian volume (\>10ml) (it is enough for 1 ovary to meet these criteria)
• • Patients with good ovarian reserve: High antral follicle count (AFC): ≥ 20 antral follicles in both ovaries or Anti-müllerian hormone (AMH) value ≥3.5 ng/ml
• • In both cases, without significant uterine or ovarian anomalies
• Exclusion Criteria:
• • There are contraindications for the administration of gonadotropins, oral contraceptives and/or other drugs used in the framework of the present study.
• • Preimplantation Genetic Testing (PGT) Cycles
• • Oocyte donation cycles
• • Medical contraindication for pregnancy.
• • High grade endometriosis (\> grade 2)
• • Cases with extremely poor sperm