ED90 of Norepinephrine and Phenylephrine Boluses Under Intensive Treatment

Launched by GENERAL HOSPITAL OF NINGXIA MEDICAL UNIVERSITY · Nov 28, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring the effectiveness of two medications, norepinephrine and phenylephrine, in treating low blood pressure that can happen after spinal anesthesia during cesarean sections. The goal is to find out the dose that works best for most patients. This study will only include women aged 18 to 45 who are having their first or later child and are at least 37 weeks pregnant. They should be in good health according to certain medical guidelines and scheduled for a cesarean section with spinal anesthesia.

If you or someone you know is eligible and chooses to participate in this trial, you can expect to receive either of the medications during the procedure if low blood pressure occurs. This study will help doctors understand how to better manage blood pressure during cesarean deliveries, which is important for the safety of both the mother and the baby. It's important to note that not everyone can participate; certain health conditions and physical criteria will be considered before enrollment.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 18-45 years
• • Primipara or multipara
• • Singleton pregnancy ≥37 weeks
• • American Society of Anesthesiologists physical status classification I to II
• • Scheduled for cesarean section under spinal anesthesia
• Exclusion Criteria:
• • Body height \< 150 cm
• • Body weight \> 100 kg or body mass index (BMI) ≥ 40 kg/m2
• • Eclampsia or chronic hypertension or baseline blood pressure ≥180 mmHg
• • Hemoglobin \< 7g/dl
• • Fetal distress, or known fetal developmental anomaly