Comparison of Efficacy Between Combination of Amitriptyline-propranolol and Pizotifen for Migraine Prophylaxis.

Launched by BANGABANDHU SHEIKH MUJIB MEDICAL UNIVERSITY, DHAKA, BANGLADESH · Nov 27, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness of two different treatments for preventing migraines. Researchers want to find out if a combination of two medications, amitriptyline and propranolol, is less effective than another medication called pizotifen in stopping migraines before they start. Participants in the study will need to keep a diary to track their headaches and take the medications as instructed during their visits. They’ll also need to reach out to the study leader if they have any questions or experience side effects from the medications.

To be eligible for this trial, participants must be between 18 and 50 years old and have a diagnosis of migraines, but not other types of headaches. They should not be currently taking any migraine prevention medications and must be willing to participate fully. It’s important that they can accurately fill out the headache diary. The trial is currently active but not looking for new participants at this time. If you or someone you know is considering participation, it’s a good opportunity to help find better ways to manage migraine symptoms.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patient of migraine (with typical aura or without aura) according to ICHD-3 (International Classification of Headache Disorder, 3rd edition) criteria.
• • 2. Age at entry: 18 to 50 years (to minimize the risks related to adverse effects of study drugs such as drowsiness, weight gain, A-V conduction block, postural hypotension)
• • 3. Patients not on any prophylactic medications.
• • 4. Patients willing to take part in the study.
• • 5. Patients being able to fill a headache diary successfully \& reliably.
• Exclusion Criteria:
• • 1. Age \<18 years or \>50 years
• • 2. Patients having headache other than migraine, complicated migraine, ophthalmoplegic migraine, catamenial migraine, basilar migraine.
• • 3. Patients on prophylactic medication.
• • 4. Co-morbidities such as heart failure, hepatic or renal impairment, diabetes, bronchial asthma, malignancy, intracranial vascular aneurysm, pregnancy \& breastfeeding etc.
• • 5. Patients having known hypersensitivity to amitriptyline, propranolol or pizotifen