The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes

Launched by LOMA LINDA UNIVERSITY · Nov 28, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how eating fresh mango affects health in people with prediabetes. Specifically, researchers want to learn if eating 1.5 cups of mango each day for 12 weeks can improve blood sugar levels, reduce insulin resistance (how well the body responds to insulin), lower bad cholesterol, and decrease inflammation in the body. They will compare the results of participants while they are eating mango to a period when they do not eat any mango to see if there are any changes in these health markers.

To participate, individuals should have a specific range of blood sugar levels (indicating prediabetes) and carry extra weight around their waist. However, those with certain health conditions, allergies to mango or latex, or who smoke or drink heavily are not eligible. Participants will need to attend several appointments over the study period for health checks and blood tests. This study could help us understand whether adding mango to the diet can be a tasty way to support better health for people at risk of diabetes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • HgbA1c of 5.7 to 6.4% indicative of prediabetes
• • Abdominal obesity as defined as a waist circumference \>102 cm for men or \>88 cm for women
• Exclusion Criteria:
• • Self-reported chronic disease history (diabetes, heart disease, cancer, kidney disease, inflammatory bowel disease, etc.)
• • Pacemaker
• • Mango allergies
• • Latex allergies (cross-reactive with mango)
• • Smoking, use of tobacco, or high alcohol intake (\>2 drinks/day for men or \>1 drink per day for women)
• • Recent significant weight loss (\>5% within 6 months of study enrollment)
• • BMI \>35 kg/m\^2
• • Pregnancy or lactation
• • Use of medication and/or supplements affecting glycemic indicators or lipids
• • Habitual mango intake of \>3 servings per week and/or habitual fruit intake of \>2 servings per day
• • Not able to read and/or communicate in English