Ventilation Using Radiographic Examination: Functional Lung Imaging Techniques for the Reduction of Toxicity in Functional Avoidance Radiation Therapy

Launched by UNIVERSITY OF SYDNEY · Dec 5, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new way to use advanced imaging techniques to improve radiation therapy for patients with lung cancer. The main goal is to see if using special scans, like fluoroscopy and CT ventilation imaging, can help doctors better target the radiation while protecting healthy lung tissue, which could lead to fewer side effects for patients. The trial involves patients who are being treated for stages II-IV non-small cell lung cancer, either with the aim to cure the cancer or to relieve symptoms.

To participate, patients need to be at least 18 years old and have a confirmed diagnosis of lung cancer, among other criteria. They will undergo several imaging tests before starting their standard radiation treatment, and these tests will be repeated after treatment to compare results. It’s important to note that there will be no changes to the patients' regular treatment plans; the scans are additional and will help researchers understand how to improve care for future patients. Participants will also need to be available for follow-ups for up to one year.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged 18 years or older.
• • Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
• • Histologically proven Stage II-IV non-small cell lung cancer as determined using the IASLC International Association for the Study of Lung Cancer (IASLC) 8th edition lung cancer staging guidelines.
• • To be treated with curative intent (stage II-III) or palliative intent (stage IV) with non-SABR external beam radiotherapy (e.g. 60 Gy in 30 treatments for curative intent or 30 Gy in 5 treatments for palliative intent).
• • Pulmonary function tests within 8 weeks of registration.
• • 4DCT simulation for radiation therapy.
• • Willingness to give written informed consent.
• • Willingness and ability to comply with the study procedures and visit requirements.
• • Available for follow up for 1 year or until death, whichever occurs first.
• Exclusion Criteria:
• • Prior radiation therapy to the thorax.
• • Prior surgery for this cancer.
• • Prior chemotherapy for this cancer.
• • Interstitial lung disease.
• • Pregnant women.