Efficacy of Flunarizine Vs Amitriptyline in Prophylaxis of Migraine Prophylaxis

Launched by SHALAMAR INSTITUTE OF HEALTH SCIENCES · Nov 30, 2023

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ClinConnect Summary

This clinical trial is designed to compare the effectiveness of two medications, flunarizine and amitriptyline, in preventing migraines. The goal is to see which medication can reduce the number of migraine attacks and the level of pain experienced by patients. The study will include 84 participants, ages 18 to 60, who have at least three migraine attacks per month and have not taken any migraine prevention medications for the past four months.

To be eligible for this trial, participants must be in good health and not have certain medical conditions, like uncontrolled high blood pressure or heart disease. They should also not be pregnant or have allergies to the medications being tested. If you join this study, you will be randomly assigned to receive either flunarizine or amitriptyline, and your migraine frequency and pain levels will be monitored over time. This trial is still in the planning stages, so no one is being recruited just yet.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Age 18- 60 years 2. Both genders 3. 3 or more migraine attacks per month 4. normal systemic and neurological examination 5. not having taken any prophylactic medication for the last 4 months
• Exclusion Criteria:
• • Un controlled hypertension 2. Ischemic heart disease, chronic liver failure and chronic liver disease 3. Pregnant patient 4. Known allergies to drug being used in study 5. Major pathology or surgery at the neck or the head 6. Recent injury or road traffic injury at the head or the cervical spine 7. Cancer pain 8. Rheumatological or immune related diseases 9. Implantable metallic or electrical devices in the head 10. Patients using opioids or user of illicit drugs or has had recent history of alcohol or drug abuse.