Chronic Endometritis and Benefits of Antibiotics in Women With Recurrent Miscarriage

Launched by CHINESE UNIVERSITY OF HONG KONG · Nov 30, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at a condition called chronic endometritis (CE) and how antibiotics might help women who have experienced multiple miscarriages without a clear reason. The main goals of the study are to see how common CE is in these women, identify the types of germs present in the uterus, and determine if treating CE with antibiotics can improve their chances of having a successful pregnancy.

To participate in this trial, women must be between the ages of 20 and 45 and have had two or more miscarriages before 24 weeks of pregnancy. However, women with certain medical conditions, like specific uterine abnormalities or autoimmune diseases, cannot join the study. Participants will receive treatment and be closely monitored to see how it affects their health and pregnancy outcomes. This study is currently recruiting participants, so if you or someone you know fits the criteria, it could be a valuable opportunity to contribute to important research on miscarriage and women's health.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Women with a history of 2 or more consecutive miscarriages before 24 weeks of gestation
• • Women aged 20-45 years old
• Exclusion Criteria:
• • Uncorrected uterine anomalies, such as the septate or bicornuate uterus, fibroids (submucous/intramural)
• • Untreated hydrosalpinx
• • Antiphospholipid syndrome
• • Known clinical autoimmune disease
• • Undergoing immunotherapy
• • Abnormal thyroid function
• • Abnormal karyotyping of couples
• • Known immunodeficiency pathologies such as diabetes or HIV
• • Currently taking other antibiotics or other trial medications or TCM;
• • Currently or previously involved in other clinical trials with medication intake;
• • Those with active pelvic inflammatory disease or suspicion of infection etc.