Hyaluronan-enriched Medium and Euploid Blastocyst Transfers

Launched by ART FERTILITY CLINICS LLC · Dec 8, 2023

Keywords

ClinConnect Summary

This clinical trial is studying whether using a special medium enriched with hyaluronan, called EmbryoGlue, can improve pregnancy outcomes for women undergoing frozen embryo transfers (FET) with genetically normal embryos. The research specifically focuses on how this medium affects the success rates of pregnancies when transferring euploid blastocysts, which are embryos that have been tested and found to have the correct number of chromosomes.

To participate in this trial, women aged 18 to 46 who have at least one healthy, frozen blastocyst available for transfer may be eligible. Participants will be part of a process that involves a short exposure of their embryos to the EmbryoGlue medium before and during the transfer. The trial is currently recruiting, and it aims to gather important information about how this new approach could potentially lead to higher rates of successful pregnancies. If you are considering joining, it’s a good idea to discuss it with your healthcare provider to see if it’s right for you.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • All frozen embryo transfer (FET) cycles with euploid blastocysts biopsied and vitrified on Day 5 after PGT-A.
• • Rank of randomization based on embryo quality.
• • Only hormonal replacement theraphy (HRT) cycle regimen.
• • Women aged 18 years to 46 years.
• • Having at least 1 chromosomally normal vitrified blastocyst(s) on Day 5 available for transfer.
• • All sperm samples.
• • BMI between 18 and 35.
• Exclusion Criteria:
• • FET cycles with preimplantation genetic testing for monogenic disorders (PGT-M) and for structural rearrangements (PGT-SR).
• • FET cycles with mosaic / aneuploid blastocysts.
• • FET cycles with unknown outcome.
• • FET cycles with Day 6 or Day 7 biopsied blastocysts.
• • FET with patients' endometrium preparation with treatments other than HRT.
• • FET where PGT-A was performed for gender selection.