GRACE: Evaluating Compression Stockings in Patients That Require Extended Duration Pharmacological Thromboprophylaxis

Launched by IMPERIAL COLLEGE LONDON · Dec 4, 2023

Keywords

ClinConnect Summary

The GRACE trial is studying whether wearing compression stockings, along with blood thinning medications, can help prevent blood clots in patients who are at high risk after surgery. Blood clots in the legs, known as deep vein thrombosis (DVT), can be very serious, especially if they travel to the lungs and cause pulmonary embolism (PE). This trial aims to find out if adding stockings to the treatment can reduce the risk of these clots even further for patients who are already receiving blood thinners.

To be eligible for this study, participants must be adults aged 18 or older who are having certain types of elective surgeries that put them at high risk for DVT. The study will randomly assign participants to either receive blood thinning medication alone or the medication plus stockings. Everyone in the trial will have a special ultrasound scan about three weeks after their surgery to check for any blood clots. Additionally, participants will have follow-up phone calls to monitor their health and any potential issues related to their treatment. This research could help determine if compression stockings are necessary, which may save costs and reduce discomfort for patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults (≥18 years of age)
• • Participants undergoing elective surgery; risk assessed as requiring EDPTP
• Exclusion Criteria:
• • Contraindications to EDPTP or GCS
• • Individuals requiring therapeutic anticoagulation e.g., anticoagulation for previous DVT
• • Known thrombophilia or thrombogenic disorder