Capture of Healthy Gut Bacteria Associated to High Fiber Diet

Launched by INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT · Dec 4, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how a high-fiber diet can help capture and study healthy gut bacteria. Researchers know that the bacteria in our intestines play an important role in our health, and eating plenty of fruits, vegetables, and whole grains is linked to having beneficial bacteria. However, many types of these good bacteria have not yet been isolated and studied. By recruiting participants who eat a lot of fiber, the trial aims to identify and cultivate these bacteria to better understand their health benefits.

To be eligible for this study, participants should be healthy adults aged 20 to 50, with a body mass index (BMI) between 18.5 and 25. They should consume more than five servings of fruits and vegetables each day and at least 25 grams of dietary fiber daily, while following a varied diet that includes little processed food. Participants can expect to contribute to important research that may lead to better health insights. It's important to note that individuals with certain health conditions, those taking specific medications, or those with lifestyle habits like smoking or excessive alcohol consumption will not be eligible for this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy adult subjects ;
• • Age between 20 and 50 (limits included) ;
• • BMI between 18.5 and 25 kg/m2 (excluding limits) ;
• • Consumption of more than 5 portions of fruit and vegetables a day;
• • Intake of at least 25g of dietary fibre per day;
• • A varied diet with little processed food.
• Exclusion Criteria:
• • Antibiotics and/or transit modulators taken in the 3 months prior to sampling;
• • Known pathologies;
• • Current treatment;
• • History of digestive surgery having an impact on the microbiota, deemed incompatible with the study (bariatric surgery);
• • Consumption of food supplements based on protein preparations, probiotics or prebiotics;
• • Smoking (even occasionally);
• • Alcohol consumption \> 2 glasses (i.e. 20 g) per day;
• • Intense sporting activity;
• • Pregnant or breast-feeding women;
• • Persons under legal protection (curatorship, guardianship, etc.);
• • Volunteers taking part in another intervention study;
• • Persons refusing to be registered on the French Ministry of Health's Fichier National des Volontaires Sains (National Register of Healthy Volunteers);
• • Subject not affiliated to the social security system;
• • Subject in a period of exclusion from a previous study or having received a total amount of compensation exceeding 6000 euros over the 12 consecutive months prior to the start of the trial (after verification in the Fichier des Volontaires pour la Recherche Biomédicale).