Bovine-derived Xenograft With or Without L-PRF for Alveolar Ridge Preservation After Tooth Extraction: a Randomized Controlled Trial

Launched by MOHAMMED BIN RASHID UNIVERSITY OF MEDICINE AND HEALTH SCIENCES · Dec 6, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a treatment approach to help preserve jawbone health after a tooth extraction, which is important for future dental implants. Researchers are specifically looking at whether adding a treatment called L-PRF (which uses a part of your blood to promote healing) to a bovine-derived bone material can improve bone healing and blood vessel growth in the area where the tooth was removed. This trial aims to see how well this method works over time for patients who need dental implants.

To be eligible for this trial, participants need to be at least 18 years old and require the extraction of a single tooth due to issues like decay or complications from previous dental treatments. They should have good oral hygiene and be committed to attending follow-up appointments. However, individuals with certain dental diseases, ongoing health issues, or specific habits that could affect their jaw health may not qualify. If you participate, you would receive either the standard treatment or the combination with L-PRF and be monitored for how well your jawbone heals and how this impacts your future dental implant.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged 18 or over.
• • Require extraction of anterior or posterior single tooth due to caries, endodontic and prosthetic complications.
• • The tooth that requires extraction is bordered by two teeth.
• • Controlled oral hygiene (full-mouth plaque and bleeding scores ≤ 25% at baseline).
• • Good compliance and commitment to attend follow-up review appointments.
• • Willing to provide informed consent.
• Exclusion Criteria:
• • Localised / generalised periodontitis.
• • Presence of acute periapical lesion.
• • Bone metabolic disease and/or taking medications that affect bone metabolism.
• • Long term use of non-steroidal anti-inflammatory medications.
• • History of malignancy, radiotherapy or chemotherapy.
• • Pregnant or lactating women.
• • Severe bruxism or parafunctional habits.
• • Large occlusal discrepancies.