Infusional FOLFOX Plus Camrelizumab and Apatinib vs HAIC-FOLFOX Plus Camrelizumab and Apatinib for Advanced HCC

Launched by SUN YAT-SEN MEMORIAL HOSPITAL OF SUN YAT-SEN UNIVERSITY · Dec 7, 2023

Keywords

ClinConnect Summary

This clinical trial is studying two different treatment combinations for patients with advanced liver cancer, specifically a type called hepatocellular carcinoma (HCC) at BCLC Stage C. The treatments being compared are one that uses intravenous FOLFOX (a type of chemotherapy) along with two other drugs, Camrelizumab and Apatinib, versus a different method called HAIC-FOLFOX, which delivers chemotherapy directly to the liver. The goal is to see which treatment works better for these patients.

To participate, individuals need to be between 18 and 75 years old, have a specific type of liver cancer that has not been treated with other first-line drugs, and be in overall good health, meaning their vital organs must function properly. They also need to have at least one measurable tumor. Participants can expect to receive the assigned treatment and will be closely monitored throughout the study. It's important to know that this trial is currently recruiting participants and that anyone interested should discuss eligibility with their healthcare provider.

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Eligibility criteria

• Inclusion Criteria:
• • 1. Patients volunteered to participate in this study and signed informed consent;
• • 2. Age 18-75, male or female;
• • 3. ECOG PS score 0-2;
• • 4. Child-pugh liver function grading: Grade A or B
• • 5. The clinical diagnosis conforms to primary hepatocellular carcinoma (HCC) and the lesion conforms to BCLC stage C
• • 6. Did not received any type of other first-line drugs such as Sorafenib
• • 7. According to RECIST 1.1 standard, patients have at least one measurable lesion (CT/MRI scan long diameter ≥10mm or CT/MRI scan short diameter ≥15mm for lymph node lesions, and the lesion has not received radiotherapy, freezing or other local treatments);
• • 8. Expected survival ≥ 12 weeks;
• • 9. The function of vital organs meets the following requirements (excluding the use of any blood component and cell growth factor within 14 days): Blood routine:White blood cells count ≥3.0×10\^9/L Platelet count ≥70×10\^9/L Hemoglobin ≥80g/L(without blood transfusion); Liver and kidney function: Serum creatinine (SCr) ≤ 1.5 times upper limit of normal value (ULN); Total bilirubin (TBIL) ≤ 1.5 times the upper limit of normal value (ULN); AST or ALT levels ≤ 3 times the upper limit of normal value (ULN)
• • 10. Women of childbearing age should agree to use contraceptives (such as intrauterine devices, contraceptives or condoms) during and within six months of the end of medication;Patients with negative serum or urine pregnancy tests within 7 days prior to study inclusion and who must be non-lactating, and males should agree to use contraceptives during the study period and for 6 months after the end of the study period.
• • 11. Subjects have good compliance and cooperate with the follow-up.
• • 12. Subjects with HBV or HCV infection should receive anti-virus treatment without interfron.
• Exclusion Criteria:
• • 1. Have received immunotherapeutic drugs or interferon in the past.
• • 2. Severe allergic reaction to other monoclonal antibodies, immunotherapy or chemotherapy.
• • 3. Female subjects with pregnancy or on feeding.
• • 4. Patients with congenital or acquired immune deficiencies.
• • 5. Abnormal coagulation function (INR\>2.0, PT\>16s), have bleeding tendency or are receiving thrombolysis or anticoagulation therapy, and allow preventive use of low-dose aspirin and low-molecular-weight heparin
• • 6. The patient has suffered from other malignant tumors at the same time (except for cured skin basal cell carcinoma and cervical carcinoma in situ)
• • 7. The patient has active infection, fever of unknown origin within 7 days (CTCAE\>2)
• • 8. Patients with congenital or acquired immune deficiencies.
• • 9. With clinical symptoms or diseases of the heart that are not well controlled.
• • According to the judgment of the investigator, the patients with factors that may affect the results of the study or cause the study to be terminated midway, such as alcoholism, drug abuse, other serious diseases (including mental illness) need to be treated together, severe laboratory abnormalities, accompanied by family or social factors, which will affect the safety of patients