A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome

Launched by DOW UNIVERSITY OF HEALTH SCIENCES · Dec 12, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how vitamin D supplements can help improve dental health, specifically in people who have early signs of tooth decay known as Initial Carious Lesions. Researchers want to see if vitamin D can prevent these lesions from getting worse compared to using fluoride treatments. Participants will be divided into three groups: one group will receive vitamin D supplements and tips on oral hygiene; another group will get both vitamin D and fluoride treatments along with hygiene tips; and the last group, who already have enough vitamin D, will only receive fluoride and hygiene tips. The study will last for six months, during which researchers will monitor changes in tooth health and the types of bacteria present in saliva.

To be eligible for the trial, participants should be between 12 and 50 years old, have at least two teeth with early signs of decay, and have a vitamin D deficiency. Some individuals may not qualify, including those with certain gum diseases, severe health issues affecting vitamin D, or those currently using specific dental products. This study is actively recruiting participants, and it aims to provide insights into how vitamin D might be an effective way to support dental health in those at risk of decay.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients of all genders and ages ranging from 12-50 years, having at least two teeth with clinically diagnosed Initial Carious Lesions at Moderate Risk of Dental Caries, after written informed consent.
• • Patients having vitamin D deficiency.
• Exclusion Criteria:
• • Patients who have heavy calculus, gingivitis, or periodontitis.
• • Patients using desensitizing toothpaste or mouthwash up to six weeks before the study.
• • Patients who have severe intestine or kidney disease, malabsorption syndrome, or any other conditions affecting vitamin D metabolism.
• • Patients on antibiotics or probiotics therapy for the last month
• • Pregnant females.
• • Patients with poor oral hygiene and with excessive dietary exposure to acids and carbohydrates.