SSM Predicts Outcomes of CLD Inpatients With Acute Liver Injury

Launched by NANFANG HOSPITAL, SOUTHERN MEDICAL UNIVERSITY · Dec 14, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a non-invasive tool called spleen stiffness measurement (SSM) to help doctors predict the health outcomes of patients with chronic liver disease (CLD) who are experiencing acute liver injury. The goal is to see if changes in spleen stiffness can help identify patients at risk of developing serious liver problems, known as acute-on-chronic liver failure (ACLF), and to understand how these changes might affect their short-term recovery over 28 and 90 days.

To be eligible for this study, participants should be between 18 and 80 years old and have chronic liver disease along with significant liver injury, indicated by high levels of a substance called bilirubin. However, individuals who have had certain liver surgeries, have severe health issues unrelated to liver disease, or are currently pregnant cannot participate. Those who join the study can expect to undergo non-invasive testing to monitor their spleen stiffness and may contribute to important research that could improve care for future patients with similar conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age between 18 years and 80 years
• • 2. Chronic liver diseases regardless of etiology
• • 3. Acute liver injury with total bilirubin ≥ 3 mg/dl regardless of inducement
• Exclusion Criteria:
• • 1. Prior surgery of liver diseases before enrollment such as liver transplantation, transjugular intrahepatic portosystemic shunt (TIPS), splenectomy and partial splenic embolization
• • 2. Severe extrahepatic diseases such as chronic obstructive pulmonary disease level IV, chronic kidney disease with end-stage renal failure, myocardial infarction within 3 months before admission
• • 3. Receiving Immunosuppressive drugs for reasons rather than chronic liver diseases
• • 4. Diagnosis of hepatocellular carcinoma or other non-liver malignancies during screening period
• • 5. Serious mental illnesses such as anxiety, depressive disorders to obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD)
• • 6. The pregnant
• • 7. Jaundice due to biliary obstruction or cholestasis
• • 8. Unsuitable to participate in this study judging by investigators