Effects of Ketone Supplementation on Acute Alcohol Withdrawal

Launched by UNIVERSITY OF PENNSYLVANIA · Dec 7, 2023

Keywords

ClinConnect Summary

This is a 5 day double-blinded, placebo-controlled intervention study of 50 treatment-seeking individuals with AUD, who are receiving detoxification treatment at Caron Treatment Center. Participants will be recruited for participation within 48 hours of admission to the inpatient unit. Participants will be consented and randomized to receive 10 g of ketone supplement three times daily (n=30; 1,3-butanediol and D-hydroxybutyric acid from Kenetik, VitaNav Inc., Washington D.C.) for 5 days or a placebo beverage (n=20). Benzodiazepines and other "comfort" medications will be administered daily ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Meets current DSM-5 criteria for AUD and admitted for alcohol withdrawal management treatment at Caron Treatment Center
• • 2. Willingness to provide signed, informed consent and commit to completing the procedures in the study
• Exclusion Criteria:
• • 1. Current, gastrointestinal (GI), liver or other clinically significant physical disease that may interfere with the intake of the Ketone Supplement based on medical history, and evaluation of the Study Physician.
• • 2. Currently pregnant or lactating, based on urine pregnancy test and clinical exam.
• • 3. Current significant withdrawal from other substances, including benzodiazepines, opioids that require medication management for withdrawal and may interfere with study results/withdrawal management plan.
• • 4. Judged by the principal investigator, Study Physician, or their designee to be an unsuitable candidate for the study.