Hyperoxia During Pulmonary Rehabilitation in Chronic Lung Disease - Does it Matter?

Launched by EASTERN SWITZERLAND UNIVERSITY OF APPLIED SCIENCES · Dec 8, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of extra oxygen during exercise for patients with chronic lung diseases, such as Chronic Obstructive Pulmonary Disease (COPD) and asthma. Specifically, it looks at whether using supplemental oxygen while exercising on a stationary bike helps patients who experience a drop in their oxygen levels when they exert themselves. Understanding this could guide future treatments for patients who struggle with low oxygen levels during physical activities.

To participate, individuals must be at least 18 years old, stable for at least three weeks (meaning they haven't had any serious health issues recently), and have a resting oxygen level of 88% or higher. They also need to show a drop in oxygen levels during a walking test. Participants will take part in exercise tests, some using supplemental oxygen and others using a placebo (sham air), without knowing which treatment they are receiving. This will help researchers determine if supplemental oxygen truly makes a difference in endurance during exercise. If you or someone you know fits these criteria and is interested in participating, this study could provide valuable insights into managing exercise-related breathing challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • We will include male and female lung disease patients undergoing pulmonary rehabilitation: aged ≥ 18 years; stable condition \> 3 weeks (e.g. no exacerbations); resting oxygen saturation (SpO2) ≥ 88% and exercise induced hypoxemia defined by a fall in SpO2 by ≥ 4% during a 6-minute walking test (6MWT); informed consent as documented by signature.
• Exclusion Criteria:
• • Severe daytime resting hypoxemia (SpO2 \< 88% or partial pressure of oxygen (PaO2) \< 8 kPa); unstable condition requiring adaptation of pharmacologic and other treatment modalities or requirement of intensive care or relevant severe concomitant disease; inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, neurological or orthopedic problems with walking disability or inability to ride a bicycle; women who are pregnant or breast feeding; enrolment in another clinical trial with active treatment.