ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)

Launched by UNIVERSITY OF WASHINGTON · Dec 7, 2023

Keywords

ClinConnect Summary

The ADAPT Study is a research trial that aims to understand why some people struggle to continue losing weight after starting a weight loss program, a situation known as a weight loss plateau. Researchers will look into how changes in metabolism (the way our bodies process food and energy) and brain function might contribute to this challenge. This study is open to individuals aged between 65 and 74 years who have a body mass index (BMI) between 30 and 50, and who can attend classes and visits for assessments.

Participants in the study can expect to take part in classes focused on healthy eating and behavior changes while also undergoing assessments to monitor their progress. It's important to note that there are certain criteria that may prevent someone from joining, such as being a current smoker, having a history of diabetes or certain medical conditions, or participating in another weight loss program. If eligible, this study could provide valuable insights into weight loss challenges and potentially contribute to better support for individuals facing similar issues.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • BMI 30.0 - 50.0 kg/m2
• • Able to attend study intervention classes and study visits/assessments
• • Independently living with access to food preparation facilities
• Exclusion Criteria:
• • Current smoker or regular use of nicotine containing products and/or cannabis
• • Heavy alcohol use (≥2 drinks/d for females, ≥3 drinks/d for males) or drug use
• • Known cognitive impairments or h/o stroke
• • Type 2 diabetes (known diagnosis or by screening A1c (≥6.5%))
• • Medical conditions (chronic diseases, cancer, MS) or labs limiting ability to participate
• • Females: currently pregnant (or 6-months postpartum of full-term pregnancy) and/or current breastfeeding
• • Use of medications with significant effects on appetite (e.g., weight loss medications, atypical antipsychotics, stimulants) and/or chronic use of anticoagulants
• • History of bariatric surgery
• • History of eating disorder
• • Current participation in a formal weight loss program
• • Prior or current participation in a research study involving weight loss
• • Weight-reduced by \>10% within past year
• • Weight \> 330 pounds (MRI limit)
• • Allergy or intolerance to or unwillingness to consume study foods provided at visit
• • MRI contraindication (e.g., implanted metal, claustrophobia)
• • Do not have a phone compatible with activity tracker or access to videoconferencing platform that will be used for the dietary intervention or other appropriate technology needed to complete study procedures
• • Any condition(s) found by the study team and confirmed with the PI(s) that make it unsafe to participate