Lung Overdistension and Abdominal Pressure Rise

Launched by UNIVERSITY OF PADOVA · Dec 7, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how changes in abdominal pressure affect lung function in patients who are on mechanical ventilation due to serious breathing problems, such as respiratory failure. Researchers want to measure different pressures in the airway and esophagus, as well as how air is distributed in the lungs, after applying a weight on the abdomen. Understanding these effects can help improve treatment strategies for patients with severe respiratory issues.

To participate in this study, patients need to be between the ages of 65 and 74 and must be receiving invasive mechanical ventilation because of significant breathing difficulties. They should also require a specific breathing trial and have a urinary catheter to help measure abdominal pressure. However, certain conditions may prevent someone from joining, such as having metal devices in the chest, severe obesity, or specific abdominal issues. If eligible, participants can expect to have their lung and abdominal pressures measured during the study to help contribute to better care for patients with respiratory distress.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Invasive mechanical ventilation in acute respiratory failure (PaO2/FiO2 \<300 mmHg)
• • Need of PEEP trial
• • Need of urinary catheter (used to measure IAP)
• Exclusion Criteria:
• • Contraindication to EIT use
• • Pacemaker or other metal device in thoracic region
• • Contraindication to abdominal weight placement
• • Surgical or traumatic incision on the abdomen
• • Severe abdominal hypertension
• • Esophageal diseases that counterindicate naso-gastric tube placement
• • Severe hemodynamic instability (norepinephrine \> 0.1 mcg/kg/min; dobutamine or dopamine \> 5 mcg/kg/min; epinephrine every dosage)
• • Severe obesity (BMI \> 35 kg/m2)
• • Need of \> 7 kg weight to reach 5 mmHg IAP increase