The Use of the CUE1/CUE1+ in People With Parkinson's Disease and Related Disorders

Launched by QUEEN MARY UNIVERSITY OF LONDON · Dec 8, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a device called CUE1, which is designed to help improve symptoms in people with Parkinson's disease and related movement disorders. Parkinson’s disease can cause a variety of challenges, including difficulties with movement, balance, fatigue, and even sleep problems. The CUE1 device is a small, non-invasive gadget that you wear on your body, like a sticker, and it provides gentle vibrations to help manage these symptoms. The trial aims to see if this device is safe and effective for people living with Parkinson's and similar conditions.

To participate in this trial, you must be over 18 years old and have a diagnosis of Parkinson's disease or related disorders, such as progressive supranuclear palsy or multiple system atrophy. You'll wear the CUE1 at home while going about your daily activities and will need to attend a few appointments to discuss your experience and complete some questionnaires about your symptoms. This study is currently recruiting participants, so if you’re interested and meet the criteria, it could be a great opportunity to contribute to research that might help improve the lives of others with similar challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults over 18 years old
• • Clinical diagnosis of idiopathic PD and related disorders including progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and vascular Parkinsonism (VaP) as well as atypical dystonias and tremor disorders and Orthostatic Tremor (OT)
• • willing to participate and written consent provided after read the participant information sheet.
• Exclusion Criteria:
• Individuals with:
• • other neurological disorders excluding idiopathic PD, related disorders such PSP, MSA, CBD, and VaP as well as atypical dystonias and tremor disorders, affecting movement, balance and gait
• • metabolic or autoimmune disorders affecting movement, balance and gait
• • acute orthopaedic disorders influencing balance control and gait
• • audiovestibular disorders including severe hearing loss
• • visual disturbances, poor eyesight
• • not able to provide written consent form to participate
• • clinical diagnosis of cognitive impairment including dementia or Alzheimer's.
• • Mental impairments (illusions, hallucinations, impulse control disorders) (self-reported)
• Technical contraindications related to CUE1 device:
• • implanted metallic or electronic devices usage
• • hypersensitivity to vibrotactile stimulation
• • skin conditions and/or open wound in the area of where the device will be positioned (e.g., sternum) if taking medicines for PD or related disorder, then on stable dose of treatment for the last three months.