Diaphragm Dysfunction After COVID-19 as Determined by Dynamic Chest Radiography

Launched by NANFANG HOSPITAL, SOUTHERN MEDICAL UNIVERSITY · Dec 14, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how the diaphragm, a muscle that helps us breathe, works in patients who have had COVID-19, especially those experiencing ongoing breathing difficulties, known as dyspnea. Researchers will use a technique called dynamic chest radiography (DCR), which takes quick, real-time images of the chest to evaluate diaphragm function. This study aims to better understand how COVID-19 may affect this important muscle and contribute to long-lasting symptoms.

To participate, you need to be at least 18 years old and have had COVID-19, with breathing issues that have lasted for more than four weeks after your initial infection. If you're healthy and haven't had any lung problems or infections recently, you might also qualify to be in a comparison group. Participants will undergo a brief imaging test that requires you to hold your breath for a short period. It's important to note that certain health conditions, like serious heart or lung diseases, may prevent you from participating. Overall, this trial aims to shed light on the impacts of COVID-19 on breathing function, which could help improve care for those suffering from long-term effects of the virus.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * COVID-19 group:
• • 1. Voluntarily sign the informed consent form;
• • 2. Aged equal to or older than 18 years old, regardless of gender;
• • 3. Inpatients with COVID-19 who mainly complain of dyspnea, dyspnea If it persists or develops and lasts for more than 4 weeks after acute COVID-19, it is related to long COVID-19; (confirmed infection with COVID-19 through nucleic acid monitoring or hospital laboratory data);
• • 4. Lung function measurements have been completed during hospitalization due to diagnosis and treatment needs;
• • 5. Be able to cooperate in completing the dynamic chest X-ray (complete the positioning of the dynamic chest X-ray for 20 seconds, and breathe calmly and forcefully during this period; be able to hold breath for at least 7 seconds).
• * Control group:
• • 1. Voluntarily sign the informed consent form;
• • 2. Aged equal to or older than 18 years old, regardless of gender;
• • 3. People from the health examination center, and the age, gender are matched in the COVID-19 group and have no previous acute or chronic cardiopulmonary disease, no abnormalities in previous lung physical examinations and lung imaging examinations, and no history of infectious diseases in the past month;
• • 4. Physical examination items are required People who are suitable for ordinary chest X-ray examination;
• • 5. Be able to cooperate in completing dynamic chest X-ray (complete dynamic chest X-ray positioning for 20 seconds, during which period, breathe calmly and forcefully, and be able to hold breath for at least 7 seconds).
• Exclusion Criteria:
• * COVID-19 group:
• • 1. Not suitable to participate in this study;
• • 2. Combined with serious life-threatening diseases, such as cardiovascular and cerebrovascular diseases, lung cancer, airway obstruction, etc.;
• • 3. Combined with pneumothorax, pulmonary insufficiency, chronic disease, interstitial disease, lung surgery history or recent planned surgery;
• • 4. Mental disorder and unable to cooperate with the operator;
• • 5. Pregnant or lactating women;
• • 6. Major radiation related to the research within 12 months before consent Exposure (participating in previous studies involving radiation exposure, the research dose is limited to 0.4mSv);
• • 7. No evidence of having been infected with the new coronavirus;
• • 8. Unable to cooperate in completing dynamic chest X-rays;
• • 9. Unable to complete lung function measurements；
• * Control group:
• • 1. Not suitable to participate in this study;
• • 2. Patients with previous acute or chronic cardiopulmonary disease, previous lung physical examination, lung imaging examination abnormalities, within the past 1 month Have a history of infectious diseases;
• • 3. Mentally abnormal and unable to cooperate with the operator;
• • 4. Pregnant or lactating women;
• • 5. Significant radiation exposure related to the research within 12 months before consent (participation in previous research involving radiation exposure, The study dose is limited to 0.4mSv); 6) Unable to cooperate in completing dynamic chest X-ray;.