SARS-CoV-2, TESTOSTERONE AND MALE FRAGILITY

Launched by IRCCS SAN RAFFAELE · Dec 18, 2023

Keywords

ClinConnect Summary

This clinical trial, titled "SARS-CoV-2, TESTOSTERONE AND MALE FRAGILITY," is investigating how testosterone levels may affect men who have COVID-19. Researchers want to understand if lower testosterone levels make men more vulnerable to getting infected with the virus or experiencing more serious health issues as a result. The study is currently looking for male participants aged 18 and older who are hospitalized for COVID-19, either confirmed by a test or strongly suspected based on their symptoms and medical images. Healthy male volunteers over 18 can also participate as a comparison group.

Participants in the trial will be asked to provide biological samples, such as blood, to help researchers analyze the connection between testosterone levels and COVID-19 outcomes. To join, men must be able to read and sign an informed consent form, which means they understand the study and agree to take part. It's important to know that those under 18 or unable to provide consent cannot participate. This trial aims to improve our understanding of how hormonal factors may influence COVID-19 in men, potentially leading to better treatment options in the future.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• Patient Cohort:
• * Male patients with an age \> 18 hospitalized in the departments dedicated to the care of patients affected by COVID-19 at the San Raffaele Hospital and with:
• • biological samples positive for SARS-CoV-2;
• • negative test but highly suggestive clinical and radiological picture;
• • patients discharged from the emergency room with biological samples positive for SARS-CoV-2;
• • ability to read and sign the informed consent
• Control Cohort:
• • healthy donors with an age\> 18 accessing the IRCCS OSR Blood Donor Center;
• • ability to read and sign the informed consent
• Exclusion Criteria:
• • People with an age \< 18;
• • incapacity to read and sign the informed consent