Remote Ischemic Conditioning for Cerebral Ischemia in Patients With Takayasu Arteritis (TARIC-1)

Launched by XUANWU HOSPITAL, BEIJING · Dec 19, 2023

Keywords

ClinConnect Summary

The TARIC-1 clinical trial is studying a treatment called remote ischemic conditioning (RIC) to see if it can help protect the brain from reduced blood flow (cerebral ischemia) in patients with Takayasu arteritis, a condition that affects the blood vessels. This study is looking for adult patients between 18 and 65 years old who have been diagnosed with Takayasu arteritis and show signs of decreased blood flow to the brain. Participants will be randomly assigned to receive either the RIC treatment or a placebo (sham treatment) while continuing their usual medication. The study will last for 24 weeks, during which researchers will track participants’ health, any side effects, and improvements in blood flow to the brain.

Eligible patients should have inactive Takayasu arteritis and must not have severe complications affecting their heart or other important organs. Throughout the trial, participants can expect regular check-ups and tests to monitor their health and the treatment's effects. This research aims to provide valuable information about the safety and effectiveness of RIC, and if successful, it may lead to larger studies in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All patients fulfilled the 1990 American College of Rheumatology Classification Criteria for TAK
• • Inactive state
• • Male and female, aged 18-65 years old
• • The presence of supra-aortic vascular involvement ( including but not limited to the left and right sides of the common carotid artery, subclavian artery, vertebral artery involvement )
• • Decreased cerebral blood perfusion in the whole brain ( compared with healthy people ) or local ( left and right brain contrast ) suggested by pseudo-Continuous arterial spin labeling ( pCASL ) -MRI
• • Voluntary participation in this study, signed informed consent
• Exclusion Criteria:
• • Complications that endanger the function of important organs, such as uncontrollable heart failure, severe heart valve disease, severe hypertension, severe myocardial ischemia, pulmonary hypertension, acute cerebral infarction, arterial dissection or aneurysm rupture, etc
• • There are serious complications, such as poorly controlled diabetes, renal insufficiency, cardiopulmonary insufficiency, mental illness or malignant tumor
• • There were moderate to severe stenosis of brachial artery in both upper limbs