Amphotericin B for Non-HIV Cryptococcal Meningitis Patients

Launched by HUASHAN HOSPITAL · Dec 11, 2023

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age more than 18 years
• • 2. HIV antibody negative
• • 3. Cryptococcal meningitis defined as a syndrome consistent with CM and one or more of: 1) positive CSF India ink (budding encapsulated yeasts), 2) C.neoformans cultured from CSF or blood, 3) positive cryptococcal antigen Lateral Flow Antigen Test (LFA) in CSF, 4) positive brain tissue representing Cryptococcus
• • 4. Having no severe immunocompromised conditions
• • 5. Informed consent to participate given by patient or acceptable representative
• Exclusion Criteria:
• • 1. Previously cryptococcal disease
• • 2. Currently receiving treatment for cryptococcal meningitis and having received ≥72 hours of anti-cryptococcal meningitis therapy in 96 hours
• • 3. Creatinine clearance lower than 80 ml/min
• • 4. Liver dysfunction (defined as ALT or AST \> 2×ULN and bilirubin \> 1.5×ULN, or ALT or AST \> 3×ULN, or bilirubin \> 2×ULN)
• • 5. Liver cirrhosis or chronic liver failure
• • 6. Pregnancy or breast-feeding
• • 7. Known allergy to study drugs
• • 8. Failure to consent - the patient, or if they are incapacitated, their responsible relative, declines to enter the study