"Adding DNA-test for Screening of HLA-DQ2 and DQ8 to Improve Early Diagnosis of Celiac Disease"

Launched by LEIDEN UNIVERSITY MEDICAL CENTER · Dec 12, 2023

Keywords

ClinConnect Summary

Celiac Disease (CD) is an immune-mediated systemic disorder elicited by the ingestion of gluten containing cereals from the normal diet, among others wheat, rye and barley. The disease is characterized by a variable combination of gluten-dependent clinical manifestations, CD specific antibodies, human leukocyte antigen (HLA)-DQ2 or HLA-DQ8 haplotypes and chronic inflammation of the small bowel\[1,2\]. T-cells in the lamina propria of the small bowel recognize the gluten peptides when they are bound to the HLA class II specificities DQ2 and/or DQ8 on antigen-presenting cells.

CD is one of t...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Phase 1:
• • age 1-18 years,
• • consultation at the LUMC for (suspicion of) CD,
• • parents have a sufficient knowledge of Dutch language,
• • written informed consent from child and/or parent
• Phase 2:
• • age 12 months to 4 years,
• • at least one of the 10 CD-related symptoms
• • not diagnosed with CD,
• • not on a GFD,
• • parents have a sufficient knowledge of Dutch language,
• • written informed consent from the parent(s)
• Exclusion Criteria:
• Phase 1 and 2:
• • no informed consent,
• • insufficient knowledge of Dutch language and/or inability to understand the information provided,
• • bleeding disorders.