Comparison of Two Different Regional Analgesia Techniques for Patients Undergoing Total Knee Arthroplasty

Launched by CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS · Dec 11, 2023

Keywords

ClinConnect Summary

This clinical trial is studying two different methods of pain relief for patients undergoing total knee replacement surgery. The goal is to find out which technique, called IPACK or selective tibial nerve block, works better to reduce pain after the surgery. Both methods will be used alongside a spinal block to help manage pain during and after the operation. Researchers will compare how much pain patients feel and how much morphine they need to take after the surgery.

To participate in this trial, you need to be at least 18 years old and scheduled for a total knee replacement surgery. You should be in good overall health, as indicated by specific classifications, and be able to give informed consent to join the study. If you have certain allergies, are on specific medications, or have certain health conditions, you may not be eligible. If you join the trial, you will receive one of the two pain relief techniques, and your recovery will be monitored to help determine which method is more effective.

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Eligibility criteria

• Inclusion Criteria:
• • American Society of Anesthesiologists classification I-III
• • 18 yo or older
• • patients scheduled for total knee arthroplasty under central spinal anesthesia
• • informed consent signed
• Exclusion Criteria:
• • Refusal or inability for informed consent
• • Known allergies to ropivacaine, acetaminophen, ibuprofen, ketorolac, morphine, ondansetron or dexamethasone
• • Secondary surgical revision
• • Opioid treatment such as morphine, hydrocodone, hydromorphone, tramadol, methadone, fentanyl, buprenorphine or codeine
• • Bleeding diathesis
• • Neurological deficit
• • Known renal insufficiency (eGFR \<45 ml/min)
• • Known hepatic insufficiency (Child score B or C)
• • Alcohol abuse