White Matter Hyperintensities in Amnestic Mild Cognitive Impairment or Alzheimer's Disease

Launched by IRCCS POLICLINICO S. DONATO · Dec 11, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring the presence of white matter hyperintensities in the brains of individuals with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease. White matter hyperintensities are areas in the brain that appear brighter on MRI scans and may indicate changes related to memory and thinking problems. The main goal of the study is to measure how much these areas are present and where they are located in the brains of people diagnosed with these cognitive conditions. By understanding these changes, researchers hope to improve how we diagnose and monitor cognitive disorders, which could lead to better treatments in the future.

To participate in this study, individuals must have a diagnosis of aMCI or Alzheimer's disease and will need to undergo a brain MRI as part of their regular check-up. The trial is open to all adults, and researchers are also including healthy participants for comparison. During the trial, participants will receive neurological assessments and imaging to help gather the necessary information. This research is an important step in understanding the brain changes associated with aMCI and Alzheimer's, which could ultimately aid in early detection and treatment options.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants diagnosed with amnestic Mild Cognitive Impairment (aMCI) or Alzheimer's Disease (AD) based on clinical assessments.
• • Individuals undergoing brain magnetic resonance imaging (MRI) at the IRCCS Policlinico San Donato as part of routine diagnostic procedures.
• • Age-matched and gender-matched healthy control subjects for comparison.
• Exclusion Criteria:
• • Individuals with cognitive impairment other than amnestic MCI or AD.
• • History of significant neurological disorders (other than MCI or AD) that may impact the study outcomes.
• • Presence of contraindications for undergoing MRI procedures.
• • Any serious medical or psychiatric condition that, in the judgment of the researchers, may interfere with the study participation or compromise the validity of the results.
• • Known history of alcohol or substance abuse that may affect cognitive function.
• • Inability or unwillingness to provide informed consent.