Chronic Remote Ischemic Conditioning in Vascular Cognitive Impairment: A Dose Escalation Study

Launched by AUGUSTA UNIVERSITY · Dec 12, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring a treatment called remote ischemic conditioning, which involves temporarily restricting blood flow to an arm to see how it affects brain health and cognitive function in older adults. The goal is to learn how different doses of this treatment influence certain blood markers related to brain health in people who have age-related changes in their brain's white matter, as seen on MRI scans. This study is important as it will help researchers prepare for a larger trial to see if this treatment can help improve cognitive function.

To be eligible for the trial, participants need to be at least 55 years old and have had an MRI in the past six months showing only mild to moderate age-related brain changes. They should be able to walk independently and perform daily activities without assistance. Participants will be asked to use a special device during the treatment, and they will need to understand the study and give their consent to take part. If you're interested in helping with this important research, this trial offers a chance to contribute to our understanding of brain health in aging.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥55 years
• • 2. Head MRI in the past 6 months showing no more than moderate age related cerebral white matter changes (Fazekas score 0-2).
• • 3. Able to walk without assistance \& independently perform basic activities of daily living.
• • 4. Able to understand this study and agree for a valid consent.
• Exclusion Criteria:
• • Prior non-lacunar (cortical) stroke. 2. Unable to cooperate with the use of the conditioning device. 3. Confounding illness that might interfere with the interpretation of results (such as active malignancy or multiple sclerosis).
• • 4. Contraindication to transient arm ischemia in either arm (such as symptomatic peripheral artery disease).