Acute Analgesic Effects of DMT on Experimentally Induced Pain in Healthy Participants

Launched by UNIVERSITY HOSPITAL, BASEL, SWITZERLAND · Dec 12, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a substance called DMT, which is a psychedelic, on pain relief in healthy people. Researchers want to understand if DMT can help reduce different types of pain, especially since there isn't much research on its potential for this purpose. Participants will experience pain that is induced through electrical stimulation, and the effects of DMT will be compared to another substance, ketamine, and a placebo (a substance with no active ingredients).

To participate in this study, you need to be between 25 and 75 years old, speak German well enough to understand the study, and be in good health without any chronic medical conditions or major psychiatric disorders. Participants should also agree to not use any illegal drugs during the study and will need to follow some guidelines after taking the study medication, like not driving or operating heavy machinery for 24 hours. If you're interested in understanding how DMT might help with pain relief, this trial could be an opportunity to contribute to important research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age between 25 and 75 years old
• • 2. Sufficient understanding of the German language
• • 3. Understanding of procedures and risks associated with the study
• • 4. Willing to adhere to the protocol and signing of the consent form
• • 5. Willing to refrain from the consumption of illicit psychoactive substances during the study 6. Willing not to operate heavy machinery for 24 hours after the study session.
• • 7. Willing to use effective birth control throughout study participation 8. Body mass index between 18-29 kg/m2 and body weight within 50 - 90kg
• Exclusion Criteria:
• • 1. Chronic or acute medical condition
• • 2. Current or previous major psychiatric disorder
• • 3. Psychotic disorder or bipolar disorder in first-degree relatives
• • 4. Hypertension (SBP\>140/90 mmHg) or hypotension (SBP\<85 mmHg)
• • 5. Hallucinogenic and/or dissociative substance use (not including cannabis) more than 15 times or any time within the previous two months
• • 6. Pregnancy or current breastfeeding
• • 7. Participation in another clinical trial (currently or within the last 30 days)
• • 8. Use of medication that may interfere with the effects of the study medication
• • 9. Tobacco smoking (\>10 cigarettes/day)
• • 10. Consumption of alcoholic beverages (\>20 drinks/week)