Effect of Sleep Extension on Ceramides in People with Overweight and Obesity

Launched by UNIVERSITY OF UTAH · Dec 21, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how getting more sleep can affect certain fats in the blood called ceramides and how the body responds to insulin in people who are overweight or obese. The goal is to see if increasing sleep time—by about 2 hours each night—can help improve these factors in adults who typically sleep less than 6.5 hours a night. Participants will be divided into two groups: one group will focus on extending their sleep, while the other will receive general health advice on topics like exercise and nutrition.

To join the study, participants need to be between 18 and 45 years old, have a body mass index (BMI) between 25 and 34.9, and report sleeping less than 6.5 hours nightly for the past six months. However, certain individuals, such as those with sleep disorders, serious health conditions, or significant weight changes, are not eligible. If you participate, you can expect to follow a structured program that emphasizes better sleep habits or receive guidance on maintaining a healthy lifestyle, all while helping researchers learn more about the relationship between sleep and health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age: 18-45 years old; equal numbers of men and women
• • 2. Body mass index (BMI): 27.5-34.9 kg/m2
• • 3. Sleep Habits: habitual self-reported average total sleep time (TST) \<6.5 hours per night for prior 6 months
• Exclusion Criteria:
• • 1. Clinically diagnosed sleep disorder or major psychiatric illness
• • 2. Evidence of significant organ dysfunction or disease (e.g., heart disease, kidney disease)
• • 3. Clinically diagnosed diabetes or fasting plasma glucose ≥126 mg/dL or HbA1c ≥6.5%
• • 4. Use of prescription drugs or substances known to influence sleep or glucose metabolism, or anticoagulant medications.
• • 5. Cancer that has been in remission less than 5 years
• • 6. Pregnant/nursing, experiencing menopause or post-menopausal
• • 7. Shift-work: current or history of within last year
• • 8. Weight change: \>10% of body weight over prior six months
• • 9. Current enrollment in weight loss or physical activity program like the Diabetes Prevention Program
• • 10. Currently smoking
• • 11. Alcohol intake\>14 drinks per week or \>3 drinks per day